Fevereiro 23 - Inventário do mês

ARA - Aumento de Risco Absoluto | ECA - Ensaio clínico aleatorizado | ITA - Intention-to-treat Analysis | MA - Meta-análise | MBE - Medicina baseada na evidência | NIT - Non-inferiority trial | NNH - Number needed to harm | NNT - Number needed to treat | PPA - Per protocol analysis | RRA - Redução do Risco Absoluto | RS - Revisão Sistemática

META-REVISÃO

Geral, Geriatria & Paliativos

Efficacy, safety, and tolerability of antidepressants for pain in adults | The BMJ

REVISÕES SISTEMÁTICAS de ECAs

Cardiovascular

Influenza Vaccination as a Prevention Therapy for Stable CAD and ACS | The AJM

Cirurgia, Ortopedia & MFR

Comparative Efficacy and Safety of Surgical Approaches for Total Hip Arthroplasty | JAMA NetOpen

COVID-19

Physical interventions to interrupt or reduce the spread of respiratory viruses | Cochrane Library

Doente crítico/urgente

The Effect of Mobilization at 6 Months after Critical Illness — Meta-Analysis | NEJM Evidence

Endocrinologia

GLP1-receptor agonists and A1c: Good for the heart but less so for the eyes? | D&MS

Psiquiatria

Nonpharmacologic/Pharmacologic Treatments of Adult Patients w/ Major Depressive Disorder | AIM

ENSAIOS CONTROLADOS E ALEATORIZADOS

Cardiovascular

Rivaroxaban vs Enoxaparin on MACE and Bleeding Risk in pre-PCI ACS - H-REPLACE | JAMA NO

Personalized Accelerated Pacing in Preclinical and Overt HFpEF - myPACE | JAMA

Exercise and Physical Activity Program in Patients w/ AF - ACTIVE-AF | JACC: Clinical Electrophysiology

Cirurgia, Ortopedia & MFR

Lobar or Sublobar Resection for Peripheral Stage IA Non–Small-Cell Lung Cancer | NEJM

High- Versus Low-Dose Exercise Therapy for Knee Osteoarthritis | AIM

Doente crítico/urgente

Continued enteral nutrition vs fasting before extubation in the intensive care unit | Lancet RM

Non-invasive ventilation after extubation in critically ill patients with obesity in France | Lancet RM

Early mobilisation on long-term cognitive impairment in critical illness in the USA | Lancet RM

Higher protein dosing in critically ill patients with high nutritional risk - EFFORT Protein | Lancet

Endocrinologia

Empagliflozin vs placebo & Linagliptin vs placebo in young people w/ T2D - DINAMO | Lancet D&E

Once-weekly basal Insulin Fc in T2D previously treated with basal insulin | Lancet D&E

Gastroenterologia & Hepatologia

Colesevelam for the treatment of bile acid diarrhoea - SINBAD | Lancet G&H

Disposable Elevator Cap Duodenoscopes and Microbial Contamination on ERCP - ICECAP | JAMA IM

Geral, Geriatria & Paliativos

Deprescribing Medications Among Elderly after hospitalization - Shed.MEDS | JAMA IM

Phase 2 Trial of Difelikefalin in Notalgia Paresthetica | NEJM

Hematologia

Allogeneic Transplantation vs CT in Intermediate-Risk Acute Myeloid Leukemia - ETAL-1 | JAMA O

Secukinumab in moderate-to-severe hidradenitis suppurativa (SUNSHINE and SUNRISE) | Lancet

Infecciologia, Microbiologia & Antimicrobianos

Treatment Strategy for Rifampin-Susceptible Tuberculosis - TRUNCATE-TB | NEJM

Respiratory Syncytial Virus Prefusion F Protein Vaccine in Older Adults | NEJM

Efficacy and Safety of an Ad26.RSV.preF–RSV preF Protein Vaccine in Older Adults - CYPRESS | NEJM

Antimicrobial stewardship prospective audit & feedback in hospitalised COVID-19-COVASP| Lancet ID

Antibiotic Prescription Audit and Feedback on Antibiotic Prescribing in Primary Care | JAMA IM

Nefrologia

Mycophenolate Mofetil Among Patients With Progressive IgA Nephropathy | JAMA Network Open

Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland | Lancet

Neurologia

Tenecteplase versus alteplase in acute ischaemic cerebrovascular events - TRACE-2 | Lancet

Argatroban + tPA vs tPA on Neurologic Function in 4.5h onset Acute Ischemic Stroke - ARAIS | JAMA

Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease | NEJM

Biosimilar Natalizumab (PB006) in Relapsing-Remitting Multiple Sclerosis | JAMA Neurology

Oncologia

Temporary treatment cessation vs continuation of 1st-line TKI in advanced RCC - STAR | Lancet Onco

Hyaluronic Acid Spacer for Hypofractionated Prostate Radiation Therapy | JAMA Oncology

Breast-Conserving Surgery with or without Irradiation in Early Breast Cancer | NEJM

Temozolomide alone vs T w/ Interferon Alfa in High-grade Gliomas | JAMA Network Open

Psiquiatria

Oral THC alone or plus cannabidiol on THC Pharmacokinetics/dynamics | JAMA Network Open

Oral vs long-acting antipsychotic treatment in early-phase schizophrenia - EULAST| Lancet Psy

Active vs sham electrostimulation in major depression in primary care (Alpha-Stim-D) | Lancet Psy

NORMAS DE ORIENTAÇÃO CLÍNICAS - GUIDELINES

Geral, Geriatria & Paliativos

Opioids in the Management of Chronic Pain: Synopsis of the 2022 Updated US VA and DoD | AIM

Opioids for Adults With Pain From Cancer or Cancer Treatment: ASCO Guideline | JCO

Imuno-mediadas

2022 ACR guideline for vaccinations in rheumatological and musculoskeletal diseases | ACR

Psiquiatria

Nonpharmacologic and Pharmacologic Treatments in Acute Major Depressive Disorder | AIM

ESTUDOS OBSERVACIONAIS

RS COM ESTUDOS OBSERVACIONAIS (com ou sem ECA)

COVID-19

Comparability of Control and Comparison Groups in Studies Assessing Long COVID | AJM

Long-term effectiveness of COVID-19 vaccines in adults | Lancet RM

Previous SARS-CoV-2 and hybrid immunity against the omicron variant and severe disease | Lancet ID

Infecciologia, Microbiologia & Antimicrobianos

Association Between Antimicrobial Stewardship Programs and Antibiotic Use Globally | JAMA NetO

Standard of care for viral haemorrhagic fevers (VHFs) | Lancet ID

HCV point-of-care vs lab-based RNA viral load on turnaround times and adhesion | Lancet G&H

Incidence of infection with MDR Gram-negative bacteria and VRE in carriers | Lancet M

Antimicrobial resistance in patients COVID-19: a systematic review and meta-analysis | Lancet G&H

Psiquiatria

Values and Preferences about Pharmacologic and Nonpharmacologic Treatments for DD | AIM

SUB-ANÁLISES DE ECAs

Cardiovascular

Bradyarrhythmias in Patients Screened for Atrial Fibrillation vs Usual Care - LOOP | JAMA Cardiology

Dietary salt replaced with potassium-enriched salt in the SSaSS | Hypertension AHA

Endocrinologia

Moderate and Vigorous Aerobic Exercise on Diabetes and Obesity: A 10-Year Follow-up | JAMA IM

Children of women w/ T2D w/ metformin vs placebo during pregnancy - MiTy Kids | Lancet D&E

Pneumologia

Long-term safety & efficacy of tezepelumab in severe uncontrolled asthma,DESTINATION| Lancet RM

COORTE, CASO-CONTROLO & COORTE TRANSVERSAL

Cardiovascular

Temporal trends in the incidence of malignancy in heart failure: a nationwide Danish study | EHJ

ICD System Shock Function, Mortality, and Cause of Death After Magnetic Resonance Imaging | AIM

Cirurgia, Ortopedia & MFR

Telemedicine postoperative care among patients Undergoing Bariatric Surgery | JAMA Network Open

Doente crítico/urgente

STANDING algorithm by interns and senior emergency physicians for causes of vertigo | AEM

Weaning from mechanical ventilation in ICU across 50 countries - WEAN SAFE | Lancet RM

Endocrinologia

SGLT2 Inhibitors vs DPP-4 Inhibitors in Patients With Type 2 Diabetes and Varying HbA1c | JAMA IM

Geral, Geriatria & Paliativos

No Opioid Strategy at Discharge After Major Urologic Cancer Surgery - NOPIOIDS | JAMA Surgery

July 2018 worldwide valsartan recall and shortage on global trends | BMJ Open

The Safety of Inpatient Health Care | NEJM

Hematologia

Gene Therapy with Etranacogene Dezaparvovec for Hemophilia B | NEJM

Infecciologia, Microbiologia & Antimicrobianos

Household Transmission of Influenza A Viruses in 2021-2022 | JAMA

Meta-investigação & MBE

US FDA Approval of Drugs Not Meeting Pivotal Trial Primary End Points, 2018-2021 | JAMA IM

Drug Characteristics and Manufacturer Spending on Direct-to-Consumer Advertising | JAMA

Nefrologia

Serum NTpBNP and cystatin C for AKI in critically ill adults in China | BMJ Open

Endovascular thrombectomy beyond 24 hours of last known well: The SELECT late study | JAMA

Serum Glial Fibrillary Acidic Protein Compared vs Neurofilament Light Chain for MS | JAMANeurology

Frontotemporal Lobar Degeneration in 9 European Countries - FRONTIERS | JAMA Neurology

Guillain-Barré Syndrome After COVID-19 Vaccination in the US | JAMA Network Open

Oncologia

Radiation and Procarbazine for Hodgkin Lymphoma and Colorectal Cancer | JAMA Oncology

Deep Learning to Differentiate Colon Carcinoma From Acute Diverticulitis in CT | JAMA NetworkOpen

INQUÉRITOS / QUALITATIVOS

Meta-investigação & MBE

Trials Using Medical Writer Support in High-Impact Oncology Journals | JAMA Network Open

Patient-Reported Outcome Measures in Oncology Drugs Approved by the EMA | JAMA Net Open

ANÁLISE ECONÓMICA

Doente crítico/urgente

Chest Pain Management using Prehospital PoC Troponin and Paramedic Risk Assessment | JAMA IM

Psiquiatria

Cost-Effectiveness of First- / Second-Step Treatment Strategies for Major Depressive Disorder | AIM

CASO CLÍNICO / IMAGEM CLÍNICA

Cardiovascular

Unmasked by Fever: Diagnosing Brugada Syndrome After Ventricular Fibrillation Arrest | AIM

An Uncommon Cause of Acute Chest Pain | JAMA Internal Medicine

Endocrinologia

Apathetic Thyrotoxicosis Presenting With New-Onset Pulmonary Hypertension | AIM

Hematologia

Massive Splenomegaly | AIM

Imuno-mediadas

ROSAH syndrome: childhood-onset arthritis, hand deformities, uveitis, and splenomegaly | Lancet R

Pseudo-Pseudo Meigs Syndrome as the Initial Presentation of Systemic Lupus Erythematosus | AIM

Infecciologia, Microbiologia & Antimicrobianos

Janeway Lesions as a Manifestation of Aortic Graft Abscess | AIM

Bivalvular Infective Endocarditis and Mural Vegetation Caused by Bartonella quintana | AIM

Man With Asymptomatic Ulcerated White Plaques on the Soft Palate | JAMA

Neurologia

MRI Features of GABA-A Receptor Antibody-Mediated Encephalitis | JAMA Neurology

OPINIÃO

REVISÃO NÃO-SISTEMÁTICA / NARRATIVA

Meta-investigação & MBE

Using Risk of Bias 2 to assess results from RCTs: guidance from Cochrane | BMJ EBM

Neurologia

Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease | Lancet Neurology

Raciocínio clínico

Five strategies for clinicians to advance diagnostic excellence | The BMJ

PERSPECTIVA

Cardiovascular

Dapagliflozin Gets Expanded Heart Failure Indication in Europe | Medscape

NICE blocks wider use of Jardiance, Forxiga in heart failure | pharmaphorum

COVID-19

Hospital masking should be optional | Sensible Medicine

Geral, Geriatria & Paliativos

The Universal Panacea: Chicken Soup | The AMJ

Friday Reflection 14: Committing and Avoiding Medical Errors | Sensible Medicine

Hematologia

The Complete Blood Count: Increasing Its Precision and Impact | AIM

Infecciologia, Microbiologia & Antimicrobianos

Cholera is back but the world is looking away | The BMJ

The Importance of Shifting Sepsis Quality Measures From Processes to Outcomes | JAMA

Meta-investigação & MBE

Platform trials: the future of medical research? | Lancet RM

AI Bot ChatGPT Passes US Medical Licensing Exams Without Cramming – Unlike Students

Chess Lessons: Human Intelligence and Imitation Learning to Support Clinical Decisions | AIM

Nefrologia

Breaking the Link Between Enrollment in Hospice and Discontinuation of Dialysis | JAMA

Neurologia

Thrombolysis Not Necessary in Mild Nondisabling Stroke: ARAMIS | Medscape

FOAMed

Cardiovascular

Amiodarone vs Digoxin for Acute Rate Control of Atrial Fibrillation in the ED - REBEL EM

Tools for Practice - #332A Jab for Your CAD

Cirurgia, Ortopedia & MFR

REBEL Core Cast 94.0 - SBO - REBEL EM - Emergency Medicine Blog

COVID-19

VIZIR RCT – Zinc For COVID-19? | JF

Is zinc the cure for COVID? | First10EM

Doente crítico/urgente

Point-Counterpoint | IV Haloperidol Is Safe For Emergency Department Use | JF

Point-Counterpoint | IV Haloperidol Should Be Avoided In The Emergency Department | JF

We should stop using the Canadian CT head rule - First10EM

EMCrit 342 - More Cardiac Arrest Mastery with PO Berve - Pre-Tidal CO2

Gastroenterologia & Hepatologia

#380 Hemochromatosis with Elliot Tapper - The Curbsiders

Meta-investigação & MBE

Clinical decision rules are ruining medicine - First10EM

ORL

#379 Hearing Loss, Tinnitus, and Meniere's Disease - The Curbsiders