Julho de 2023 - Inventário do mês

TABELA DE CONTÉUDOS:

1. META-REVISÃO

2. REVISÕES SISTEMÁTICAS DE ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

3. ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

4. NORMAS DE ORIENTAÇÃO CLÍNICA

5. OBSERVACIONAIS

   1. Revisões Sistemáticas

   2. Primários

   3. Casos clínicos e séries

6. OPINIÃO

   1. Revisões narrativas | Perspectiva | FOAMed

Glossário:

✔✔✔ --> Muito relevante e interessante

✔ --> Relevante e interessante

(sem símbolo) --> Interessante mas pouco relevante

(sem símbolo) --> Pouco relevante e interessante

✗ --> Não relevante e pouco interessante (mas importante por contrariar hipóteses, práticas, ...)

classificação pessoal, nem todos concordarão

META-REVISÃO

Cardiovascular

✔✔✔ P2Y12 Inhibitor or Aspirin Monotherapy for Secondary Prevention of Coronary Events | JACC

Meta-investigação & MBE

✔ Scoping Review of Published Oncology Meta-analyses in High-Impact Oncology Journals | JAMA Network Open

REVISÕES SISTEMÁTICAS de ECAs

tabela de conteúdos ↟

Imuno-mediadas

✔ Janus Kinase Inhibitors for Alopecia Areata | JAMA Network Open

ENSAIOS CONTROLADOS E ALEATORIZADOS

tabela de conteúdos ↟

Cardiovascular

✔✔✔ Enoxaparin to Prevent Symptomatic VTE in Hospitalized Older Adult Medical Patients - SYMPTOMS | NEJM Evidence

Endocrinologia

✔ Oral semaglutide 50 mg taken once per day in adults with overweight or obesity - OASIS 1 | Lancet

✔ Oral orforglipron in patients with type 2 diabetes: a multicentre, randomised, dose-response, phase 2 study | Lancet

✔ Time-Restricted Eating Without Calorie Counting for Weight Loss in a Racially Diverse Population | AIM

✔ Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes | Lancet

✔ Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes - SURMOUNT-2 | Lancet

Once-daily oral semaglutide 25 mg and 50 mg vs 14 mg in adults with type 2 diabetes - PIONEER PLUS | Lancet

Co-administered once-weekly cagrilintide 2·4 mg with once-weekly semaglutide 2·4 mg in type 2 diabetes | Lancet

Geral, Geriatria & Paliativos

✗ Opioid analgesia for acute low back pain and neck pain: a randomised placebo-controlled trial - OPAL | Lancet

Infecciologia, Microbiologia & Antimicrobianos

✔✔✔ Clinical Decision Rule to Enable Direct Oral Challenge in Patients w/ Low-Risk Penicillin Allergy, PALACE|JAMAIM

✗ High-dose dual-antibiotic loaded cement for hip hemiarthroplasty in the UK - WHiTE 8 | Lancet

Neurologia

Recombinant Human Prourokinase in the Treatment of AIS w/ 4.5H of Stroke Onset - PROST | JAMA Network Open

Donanemab in Early Symptomatic Alzheimer Disease | JAMA Neurology

✗ Trial of Solanezumab in Preclinical Alzheimer’s Disease | NEJM

✗ Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons | NEJM

Pneumologia

Cytisinicline for Smoking Cessation - ORCA-2 | JAMA ( --> Cytisine vs Varenicline on Smoking Cessation | JAMA )

Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts - BOREAS | NEJM

Psiquiatria

✗ Transcranial direct current stimulation additional to SSRIs in major depressive disorder - DepressionDC | Lancet

NORMAS DE ORIENTAÇÃO CLÍNICAS - GUIDELINES

tabela de conteúdos ↟

Doente crítico/urgente

Evaluation and Management of Emergency Department Patients w/ Suspected Appendicitis - ACEP | AEM

Imuno-mediadas

Pan American League of Associations for Rheumatology for the treatment of ANCA-associated vasculitis | Lancet R

ESTUDOS OBSERVACIONAIS

REVISÕES SISTEMÁTICAS COM ESTUDOS OBSERVACIONAIS (com ou sem ECA)

tabela de conteúdos ↟

Endocrinologia

Diagnostic challenges in cyclic Cushing's syndrome: a systematic review | Lancet Diabetes & Endocrinology

Enteroviruses and risk of islet autoimmunity or type 1 diabetes | Lancet D&E

Geral, Geriatria & Paliativos

Evaluation of Population-Level Tobacco Control Interventions and Health Outcomes | JAMA Network Open

Infecciologia, Microbiologia & Antimicrobianos

Screening for Latent Tuberculosis Infection in Solid Organ transplant recipients to predict active disease | OFID

Meta-investigação & MB

✔ Does value-based healthcare support patient-centred care? A scoping review of the evidence | BMJ Open

✔ Prevalence and predictors of data and code sharing in the medical and health sciences: SR w/ MA of IPD | BMJ

Neurologia

✔ STANDING algorithm performed by interns and senior emergency physicians for central causes of vertigo | AEM

PRIMÁRIOS - SUB-ANÁLISE / COORTE / CASO-CONTROLO / INQUÉRITOS / A. ECONÓMICAS

tabela de conteúdos ↟

Cardiovascular

✔ Accelerometer-derived “weekend warrior” physical activity and incident cardiovascular disease | JAMA

✔ Low-Dose Aspirin and the Risk of Stroke and Intracerebral Bleeding in Healthy Older People | JAMA NO

✔ Decompression illness in divers with or without patent foramen ovale: A cohort study | AIM

Indefinite Anticoagulant Therapy for First Unprovoked Venous Thromboembolism | AIM

✗ Bempedoic Acid for Primary Prevention of CVE in Statin-Intolerant Patients - CLEAR subanalysis | JAMA

Diagnóstico e Raciocínio Clínico

✔ History of Present Illness Summaries Generated by a Chatbot and Senior Internal Medicine Residents | JAMA IM

✔ Chatbot vs Medical Student Performance on Free-Response Clinical Reasoning Examinations | JAMA IM

✔ Safety of the pulmonary embolism rule-out criteria rule: Findings from the RIETE registry | AEM

Real-life assessment of BioFire FilmArray pneumonia panel in adults hospitalized with respiratory illness | JID

Reliability of admission procalcitonin testing for capturing bacteremia across the sepsis spectrum | CC

Doente crítico/urgente

Success rates of lateral canthotomy and cantholysis for treatment of orbital compartment syndrome | AJEM

Endocrinologia

Global, regional and national burden of diabetes from 1990 to 2021 w/ projections to 2050: systematic analysis | Lancet

Gastroenterologia & Hepatologia

✔ Early Plasmapheresis Among Patients w/ Hypertriglyceridemia–Associated Acute Pancreatitis - PERFORM | JAMA NO

Imunomediadas

Comparative Effectiveness of SGLT2 for Recurrent Gout Flares and Gout-Primary ED Visits and Hospitalizations | AIM

Infecciologia, Microbiologia & Antimicrobianos

✔ Definitions of Urinary Tract Infection in Current Research: A Systematic Review | OFID

A pathology-based case series of influenza- and COVID-19-associated pulmonary aspergillosis | AJCCM

Meta-investigação & MBE

✔ Analysis of studies pertaining to masks in Morbidity and Mortality Weekly Report | medrxviv

CASOS CLÍNICOS e SÉRIES DE CASOS

tabela de conteúdos ↟

Gastroenterologia & Hepatologia

Colitis Associated With Sevelamer Carbonate: A Case Report | AIM

Geral, Geriatria & Paliativos

Popeye Sign in Hereditary Transthyretin Amyloidosis | JAMA Neurology

Imuno-mediadas

RS3PE: A Rheumatic Presentation of Lung Malignancy | AIM

Role of Muscle Biopsy in Undifferentiated Myositis, a Case Report | AJM

OPINIÃO

REVISÃO NÃO-SISTEMÁTICA / NARRATIVA

tabela de conteúdos ↟

Infecciologia, Microbiologia & Antimicrobianos

High risk and low prevalence diseases: Orbital cellulitis | AJEM

PERSPECTIVA

tabela de conteúdos ↟

Diagnóstico e Raciocínio Clínico

Evaluation of Venous Congestion by Point-of-Care Ultrasound: State of the Art | RPMI

Geral, Geriatria & Paliativos

Leveraging Goals of Care Interventions to Deliver Personalized Care Near the End of Life | JAMA Oncology

Morte Provocada a Pedido do Próprio, Opinião de Sócios da SPMI | RSPMI

Infecciologia, Microbiologia & Antimicrobianos

Mycoplasma pneumoniae: gone forever? | Lancet Microbe

Meta-investigação & MBE

✔✔✔Study of the Week Looks Back and Asks One Question: What's going on with medical science? | SensibleMedicine

✔ The 4 stages of evidence enlightenment | Munro Report

NOTÍCIAS

Geral, Geriatria & Paliativos

Aspartame is “possibly carcinogenic” but current recommended intake is safe, experts rule | BMJ

✔✔✔ FOAMed

tabela de conteúdos ↟

Diagnóstico e Raciocínio Clínico

Tiny Tips: The 6 S’s Mnemonic for Mitigating Cognitive Bias in the Emergency Department | CanadiEM

Doente crítico/urgente

REBEL Cast Ep119: A Discussion with Scott Weingart on the CT FIRST Trial | RebelEM

St.Emlyn's - ICS #SOA23 – Day 1 + ICS #SOA23 – Day 2 + ICS #SOA23 – Day 3

EMCrit 352 – Airway Update 2023

SGEM#408: HEY, I, OH I’M STILL ALIVE – IS IT DUE TO TXA? | SGEM

PATCH-trauma: Another negative (but complicated) TXA trial | First10EM

Endocrinologia

The SQuID Protocol (Subcutaneous Insulin in Diabetic Ketoacidosis): Impacts on ED Operational Metrics | AEM

Gastroenterologia & Hepatologia

Geral, Geriatria & Paliativos

Statins in Older Adults - #334 TFP

#404 Hematuria with Dr. Derek Fine | Curbsiders

Infecciologia, Microbiologia & Antimicrobianos

SGEM#409: SAME AS IT EVER WAS – TAMIFLU FOR INFLUENZA? | SGEM

Meta-investigação & MBE

Stats for Average People – What is a p-value? | Journal Feed

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ARA - Aumento de Risco Absoluto | EBM - Evidence-based medicine | ECA - Ensaio controlado e aleatorizado | ITT - Intention-to-treat Analysis | MA - Meta-análise | MBE - Medicina baseada na evidência | NIT - Non-inferiority trial | NNH - Number needed to harm | NNT - Number needed to treat | PPA - Per protocol analysis | RR - Redução Relativa | RRA - Redução do Risco Absoluto | RS - Revisão Sistemática