Março 23 - Inventário do mês

Neste inventário mensal deixo uma lista com todos os artigos com que me fui deparando. Como nem todos são muito relevantes ou modificadores de prática mas apenas pessoalmente interessantes ou importantes para alertar nuances, resolvi começar a usar uma forma de os sinalizar e diferenciar. Em última instância, isto é tudo muito subjectivo e relacionado com o meu interesse particular de médico generalista e internista português de base hospitalar.

Glossário*:

✔✔✔ --> Muito relevante e interessante

✔ --> Relevante e interessante

(sem símbolo) --> Interessante mas pouco relevante

(sem símbolo) --> Pouco relevante e interessante

✗ --> Não relevante e pouco interessante (mas importante por contrariar hipóteses, práticas, ...)

*classificação pessoal, nem todos concordarão

TABELA DE CONTÉUDOS:

1. META-REVISÃO

2. REVISÔES SISTEMÁTICAS DE ECAs

3. ECAs

4. NORMAS DE ORIENTAÇÃO CLÍNICA

5. OBSERVACIONAIS

   1. Revisões Sistemáticas | Sub-análises de ECAs | Coortes e casos-controlo

   2. Séries e casos

   3. Inquéritos | Análises económicas

6. OPINIÃO

   1. Revisões narrativas | Perspectiva | FOAMed

REVISÕES SISTEMÁTICAS de ECAs

tabela de conteúdos ↟

Cardiovascular

✔ CRT Improves Outcomes in Patients w/ Intraventricular Conduction Delay But Not RBBB | CIRCULATION

Doente crítico/urgente

✔✔✔ Effect of Corticosteroids on Mortality and Clinical Cure in Community-Acquired Pneumonia | CHEST

✔✔✔ Epinephrine in OHCA: NMA and Subgroup Analyses of Shockable and Nonshockable Rhythms | Chest

✔✔✔ Clinical outcomes in aggressive and non-aggressive IV hydration for acute pancreatitis | Critical Care

Infecciologia, Microbiologia & Antimicrobianos

✔✔✔ SARS-CoV-2 vaccines efficacy and dose–response relationship with antibodies | Lancet Microbe

✔ Effects of remdesivir in patients hospitalised with COVID-19 | Lancet Respiratory Medicine

The association between PCSK9 inhibitor use and sepsis | AJM ✗

Meta-investigação & MBE

✔ Quality of control groups in randomized trials of multiple myeloma enrolling in the USA | Lancet Hematology

✔ Clinical Trials Portfolio and Regulatory History of Idelalisib in Indolent Non-Hodgkin Lymphoma | JAMA Internal Med

✔ Meta-Analysis of Candidate Surrogate End Points in Advanced Prostate Cancer | NEJM Evidence

Oncologia

1st-line Systemic Treatment for Metastatic Castration-Sensitive Prostate Cancer | JAMA Oncology - Spin

Organ-specific immune checkpoint inhibitor treatment in lung cancer | BMJ Open

Urologia

✔ Antimuscarinics plus alpha-blockers in BPH with urinary storage symptom of BPH | Urology

ENSAIOS CONTROLADOS E ALEATORIZADOS

tabela de conteúdos ↟

Cardiovascular

✔✔✔ Rule-out of non-STE ACS by a single Troponin test - ARTICA | EHJ

✔✔✔ Routine Invasive vs Conservative Strategy in Older Frailty Adults w/ NSTEMI-MOSCA-FRAIL | JAMA IM

✔ Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension - STELLAR | NEJM

✔ Non-physician community health-care provider-led vs standard BP intervention - CRHCP | Lancet

✔ Rate-Adaptive Atrial Pacing for Heart Failure With Preserved Ejection Fraction - RAPID-AF | JAMA

✔ Efficacy and safety of the oral PCSK9 inhibitor MK-0616: a phase 2b randomized controlled trial | JACC

✔ Eliminating Medication Copayments for Low-income Older Adults at High Cardiovascular Risk | CIRCULATION

Treat-to-Target or High-Intensity Statin in Patients w/ CAD - LODESTAR | JAMA

Acute Effects of Coffee Consumption on Health among Ambulatory Adults - CRAVE | NEJM

Ambulatory Decision Support Tools to Improve Heart Failure Care - BETTER CARE_HF | JACC

Immediate vs staged complete revascularisation in ACS and multivessel CD - BIOVASC | Lancet

Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients - CLEAR | NEJM

Transcatheter Repair for Patients with Tricuspid Regurgitation - TRILUMINATE | NEJM

Endovascular Ultrasound Renal Denervation to Treat Hypertension | JAMA

Doente crítico/urgente

✔✔✔ Hydrocortisone in Severe Community-Acquired Pneumonia - CAPE COD | NEJM

✔ Lateral Decubitus or Upright Positioning Optimal for LP Success in a Teaching Hospital? | JEM

✔ Low vs standard calorie and protein in ventilated shocked patients, NUTRIREA-3 | Lancet RM - Controlo não standard

✗ Efficacy and Safety of Early Administration of 4F-PCC in Trauma at Risk of Massive Transfusion - PROCOAG | JAMA

Endocrinologia

✗ Effects of Time-Restricted Eating on Nonalcoholic Fatty Liver Disease - TREATY-FLD | JAMA Network Open

Gastroenterologia & Hepatologia

One-food vs six-food elimination diet for the treatment of eosinophilic oesophagitis | Lancet G&H - pq não 0-food?

Etrasimod as induction and maintenance therapy for ulcerative colitis - ELEVATE UC 52 + 12 | Lancet - sem comparador

Over-the-Scope Clips vs Standard Endoscopy as the Initial Treatment in Nonvariceal UGIB | AIM - sem melhoria clínica

✗ Semaglutide 2·4 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis | Lancet G&H

Geral, Geriatria & Paliativos

✔ Genicular nerve block for pain management in knee OA | AR

Hematologia

Garadacimab (FXIIa inhibitor) for hereditary angioedema prevention - VANGUARD | Lancet - Sem comparador activo

✗ Ferric carboxymaltose vs oral iron for preop IDAnaemia in colorectal cancer - FIT | Lancet G&H - Spin

Imuno-mediadas

✔ Temporary Methotrexate Discontinuation in RA for 1W vs 2W on Influenza Vaccination | A&R

✔ Treatment with rituximab in polymyalgia rheumatica - BRIDGE-AMR | Lancet Rheumatology

Baricitinib for SLE: a double-blind RC phase 3 trial - SLE-BRAVE-I | Lancet - Sem comparador activo

Baricitinib for SLE: a double-blind RC phase 3 trial - SLE-BRAVE-II | Lancet - Sem comparador activo

Lebrikizumab for Moderate-to-Severe Atopic Dermatitis - ADvocate 1 & ADvocate 2 | NEJM - Sem comparador activo

Vedolizumab for the Treatment of Chronic Pouchitis | NEJM - Sem comparador activo

Infecciologia, Microbiologia & Antimicrobianos

✔ Multifaceted antibiotic stewardship for suspected UTI in frail older adults - ImpresU | The BMJ

✔ Electronic nudges to increase influenza vaccination uptake in Denmark | Lancet - Giro...mas clinicamente relevante?

IV doxycycline vs azithromycin vs both in Severe Scrub Typhus (O. tstutsugamushi) - INTEREST | NEJM - Spin

✗ Proph, High-dose proph, and therapeutic AC in Hypoxemic COVID-19 Pneumonia - ANTICOVID | JAMA IM - Spin

Neurologia

✔✔✔ High-Intensity Interval Walking Training for Stroke Patients | JAMA Neurology

Oncologia

✔Lenvatinib + Transarterial Chemoembolization as 1st-Line for Advanced Hepatocellular Carcinoma - LAUNCH | JCO

Pneumologia

✔ Effects of Opt-out vs Opt-in Tobacco Treatment on Engagement, Cessation, and Costs | JAMA IM

Digital measurement of medical adherence and lung function in uncontrolled asthma - INCA Sun | Lancet RM - clinicamente relevante?

Psiquiatria

Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression | NEJM - Melhor tratamento disponível?

✗ Integrating Alcohol-Related Prevention and Treatment Into Primary Care | JAMA IM - Sobrediagnóstico?

Técnicas, POCUS, Exames & Outros

✔ Hyperfractionationed RT for locally advanced recurrent nasopharyngeal carcinoma | Lancet

NORMAS DE ORIENTAÇÃO CLÍNICAS - GUIDELINES

tabela de conteúdos ↟

Cardiovascular

✔ High sensivity Troponin for Evaluation and Diagnosis of Acute Chest Pain - Consensus | Circulation

Doente crítico/urgente

Surgical Management and Mechanical Circulatory Support in High-Risk PE | Circulation

Gastroenterologia & Hepatologia

✔ Management of Acute Lower Gastrointestinal Bleeding: An Updated ACG Guideline | AJG

ESTUDOS OBSERVACIONAIS

REVISÕES SISTEMÁTICAS COM ESTUDOS OBSERVACIONAIS (com ou sem ECA)

tabela de conteúdos ↟

Cardiovascular

Ionising radiation and cardiovascular disease: systematic review and meta-analysis | BMJ - clinicamente relevante?

Dermatologia

✔ Prevalence of misdiagnosis of cellulitis: A systematic review and meta-analysis | JHM

Doente crítico/urgente

✔ Diagnostic accuracy of the physical exam in ED patients with acute vertigo or dizziness: SR & MA for GRACE-3 | AEM

Geral, Geriatria & Paliativos

Potentiality of algorithms and AI adoption to improve medication management in primary care | BMJ

Infecciologia, Microbiologia & Antimicrobianos

✔✔✔ Past SARS-CoV-2 infection protection against re-infection | Lancet

✔ Prevalence of misdiagnosis of cellulitis: A systematic review and meta-analysis | JHM

Meta-investigação & MBE

✔ Challenges of Shared Decision-making in Low-risk Differentiated Thyroid Cancer | JAMA OHN

Psiquiatria

Peripheral cytokines and inflammatory proteins in acute/chronic stages of schizophrenia | Lancet Psy

SUB-ANÁLISES DE ECAs

tabela de conteúdos ↟

Cardiovascular

✔✔✔ Time course of death after ACS treated with dual antiplatelet therapy for one year | AJM

✔✔✔ REVIVED-BCIS2 subanalysis | ACC 2023 meeting

✔ 3y Outcomes After TAVI or SAVR in Low-Risk Patients with Aortic Stenosis | JACC

Cirurgia, Ortopedia & MFR

5-Year Survival of Laparoscopy-Assisted vs Open Distal Gastrectomy for Advanced Gastric Cancer | JAMA Surgery

Infecciologia, Microbiologia & Antimicrobianos

Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19 | JAMA

Meta-investigação & MBE

Bayesian Statistics to Reanalyze Data From the RCTs on Optimal Transfusion Ratios | JAMA Network Open

NLP of EHRs to Measure GoC Discussions as a Clinical Trial Outcome | JAMA Network Open

Oncologia

✔ QoL w/ pembrolizumab vs placebo plus CT in persistent, recurrent or metastatic cervical cancer - KEYNOTE-826 | Lancet Oncology

COORTE E CASO-CONTROLO

tabela de conteúdos ↟

Cardiovascular

✔✔✔ Effect of IV antihypertensives in severe HT in hospitalized patients | Hypertension

✔✔✔ Differential effect of anticoagulation according to cognitive function and frailty in AF | JAGS

✔✔✔ Benefits and harms of OAC for AF in nursing home residents with advanced dementia | JAGS

✔ LIVE HCM | ACC 2023 Meeting

✔ Incidence of Cardiac Arrest During Sports Among Women in the European Union | JACC

✔ Hyperacute T Wave in the Early Diagnosis of Acute Myocardial Infarction | AEM

Cardiovascular risk factor prevalence, treatment, and control in US Adults aged 20 to 44 years | JAMA

Lifelong endurance exercise and its relation with coronary atherosclerosis - Master@Heart | European Heart Journal

✗ Early peripheral vascular interventions for claudication, late interventions and progression to chronic ischemia | JVS - bom exemplo do que não se deve fazer

Cirurgia, Ortopedia & MFR

✔ Low serum creatinine and associated outcomes after nonemergent inpatient surgery | AS

✔ Perioperative assessment of frailty and 1-year mortality | JAMA Surgery

Surgeon-Anesthesiologist Dyad and Postoperative Outcomes | JAMA Surgery

IVC filter retrievals: Success rate and predictors of adverse events at a large specialized referral center | AJR

Doente crítico/urgente

✔ Prevalence of pulmonary embolism among patients with recent onset of dyspnea on exertion | JTH

✔ Electrocardiographic findings associated with early clinical deterioration in acute pulmonary embolism | AEM

✔ ETCO2 at ED Triage vs Triage Vital Signs in Predicting In-Hospital Mortality and ICU admission | AEM

✔ Continued vs Paused Chest Compressions During Cardiac Arrest in the ED | Resuscitation

✗ Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock | JAMA IM

Endocrinologia

✔✔✔Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia | NEJM Evidence

✔ Serum sodium, cognition and incident dementia in the general population | AaA

✔ Long-Term Changes in the Size of Pituitary Microadenomas | AIM

Geral, Geriatria & Paliativos

✔ ✔ ✔ FDA Mandate Limiting Acetaminophen/Opioid Combination Opioid Products and outcomes | JAMA

✔ Pharmaceutical Industry Payments to Physicians and Hyaluronic Acid Administration | JAMA Internal Medicine

✔ Tell-a provider about tele: Reducing overuse of telemetry across 10 hospitals in a safety net system

Agressive EOL Care among Metastatic Cancer | JAMA NO

Imuno-mediadas

Interstitial Lung Disease in Rheumatoid Arthritis Treated With Biologic and Targeted Synthetic DMARDs | JAMA NO

Infecciologia, Microbiologia & Antimicrobianos

✔✔✔ Real-world Application of Oral Therapy for Infective Endocarditis | Clinical Infectious Diseases

✔✔✔ Positive impact of PET/CT on mortality in SA bacteremia explained by immortal time bias | CID

✔✔✔ Association of PPI with Risk of Acquiring Drug-Resistant Enterobacterales | JAMA Network Open

✔ Prevention of non-ventilator-associated hospital-acquired pneumonia in Switzerland | Lancet Infectious Diseases

✔ Optimal duration for hospitalized patients with complicated UTIs and associated bacteremia | CID

✔ Penicillin susceptibility among MSSA osteoarticular infections in children | AAC

Prevalence and Clinical Outcomes of RSV vs Influenza in Adults Hospitalized with Acute Respiratory Illness | CID

Meta-investigação & MBE

The evidence base for US joint commission hospital accreditation standards: cross sectional study | BMJ

Trends of Randomized Clinical Trials Citing Prior Systematic Reviews, 2007-2021 | JAMA Network Open

Neurologia

✔✔✔ Population-based evaluation of total protein in cerebrospinal fluid | MCP

✔ Conversion Between the Montreal Cognitive Assessment and the Mini-Mental State Examination | AGS

Placental growth factor as a sensitive biomarker for vascular cognitive impairment | A&D

Visual Creativity in Frontotemporal Dementia | JAMA Neurology

Serum NfLC at Disease Onset and Worsening after First Demyelinating MS | JAMA Neurology

Seasonality of human sleep: Polysomnographic data of a neuropsychiatric sleep clinic | Frontiers

Oncologia

✔ Fifteen-year outcomes after monitoring, surgery, or radiotherapy for prostate cancer | NEJM

ERBB2-Low Breast Cancer Among Patients in the National Cancer Database | JAMA Oncology

Pneumologia

Stepping up IC dose in Asthma | JACIP

Técnicas, POCUS, Exames & Outros

✔✔✔ Diagnostic accuracy of a pragmatic, ultrasound-based approach to suspected acute appendicitis in the ED | EMJ

CASOS E SÉRIES

tabela de conteúdos ↟

Cardiovascular

Platypnea-Orthodeoxia Syndrome: A Rare Cause of Hypoxia | AIM

Brugada Pattern, Tall Peaked T Waves, Absence of P Waves, and Broad QRS Complexes | JAMA Internal Medicine

Cirurgia, Ortopedia & MFR

Left-Sided Acute Appendicitis With Situs Inversus Totalis | AIM

Dermatologia

Erythema Gyratum Repens Secondary to Pulmonary Tuberculosis | AIM

Fibrofolliculomas: The Clue to the Diagnosis of Birt-Hogg-Dubé Syndrome | AMP

Amyopathic Dermatomyositis Manifesting w/ Marked Unilateral Eyelid Swelling and Hyperpigmentation | AIM

Doenças Raras

Mundane Manifestations of Rare, but Underdiagnosed, Diseases in Portugal: The Example of McArdle Disease | AMP

Endocrinologia

A Patient With Diabetes and Spontaneous Blistering of the Right Lower Extremity | JAMA

Hematologia

Swollen gums in a young adult | BMJ

Imuno-mediadas

Infecciologia, Microbiologia & Antimicrobianos

An Uncommon Cause of Severe Polyradiculopathy | AIM

A Man With Asymptomatic Ulcerated White Plaques on the Soft Palate | JAMA

Neurologia

Pro-Ictal State in Human Temporal Lobe Epilepsy | NEJM Evidence

A Young Man With Recurrent Syncope | AIM

Pneumologia

Lungs of a Chronic Smoker: The Case of Heroin-Induced Emphysema in a 35-Year-Old Man | AIM

Erasmus Syndrome: An Underrecognized Entity | AMP

INQUÉRITOS

tabela de conteúdos ↟

Geral, Geriatria & Paliativos

✔✔✔ Assessment of Patient Education Delivered at Time of Hospital Discharge | JAMA Internal Medicine

Meta-investigação & MBE

✔✔✔ Political endorsement by Nature and trust in scientific expertise during COVID-19 | Nature

✔✔✔ Public reporting of clinical trial findings as an ethical responsibility to participants: a qualitative study | BMJ Open

Nefrologia

✔ Value Placed on Comfort vs Life Prolongation Among Patients Treated With Maintenance Dialysis | JAMA IM

OPINIÃO

REVISÃO NÃO-SISTEMÁTICA / NARRATIVA

tabela de conteúdos ↟

Cardiovascular

Cardiac Amyloidosis | AIM

Gastroenterologia & Hepatologia

Diagnosis and management of autoimmune hepatitis | The BMJ

Imuno-mediadas

Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management | BMJ

Neurologia

✔ Endovascular treatment for basilar artery occlusion: a meta-analysis | BMJ SVN

Técnicas, POCUS, Exames & Outros

Indications, Clinical Impact, and Complications of Critical Care TEE: A Scoping Review | SAGE

PERSPECTIVA

tabela de conteúdos ↟

Gastroenterologia & Hepatologia

✔✔✔ Interpreting the results from the first RCT of colonoscopy: does it save lives? | BMJ-EBM

Geral, Geriatria & Paliativos

✔✔✔ Diagnostic Stewardship to Prevent Diagnostic Error | JAMA

Infecciologia, Microbiologia & Antimicrobianos

✔✔✔ Can the Future of ID Escape the Inertial Dogma? Shorter Is Better and Oral Is the New IV | OFID

As Superbugs Flourish, Bacteriophage Therapy Recaptures Researchers Interest | JAM

H5N1: Governments should invest in vaccines for all flu strains, says WHO chief scientist | BMJ

Meta-investigação & MBE

✔ Omission of Critical Information From Clinical Trial Reports—What to Do | JAMA Oncology

Digitally enabled decentralised research: opportunities to improve the efficiency | BMJ EBM

A Transparência da Ciência com o ChatGPT e as Ferramentas Emergentes de Inteligência Artificial | AMP

Oncologia

✔✔✔ Dear Oncology Fellows: We Must All Stand Up For Patients | Sensible Medicine

Psiquiatria

✔ NICE recommends online therapies to treat depression and anxiety in adults | BMJ

Técnicas, POCUS, Exames & Outros

Critical Care TEE for the Resuscitation of Shock: An Important Diagnostic Skill for the Modern Intensivist | CHEST

✔✔✔ FOAMed

tabela de conteúdos ↟

Cardiovascular

#386 Primary Aldosteronism, MRAs, and Renovascular Hypertension: NephMadness Pod Crawl 2023 | Curbsiders

Cirurgia, Ortopedia & MFR

#336 ASA in TKA and THA Patients: Back to the future for VTE prophylaxis? - Tools for practice

Doente crítico/urgente

Role of Point-of-Care Ultrasound in Emergency Airway Management Outside the Operating Room | Analgesia

Geral, Geriatria & Paliativos

Episode 64 – Stopping the Shakes – The Curious Clinicians

Episode 63 – Getting Swol – The Curious Clinicians

Meta-investigação & MBE

Do not fear AI, pony humans | St. Emlyn's

Nefrologia

Vacillation in Atrial Fibrillation on Hemodialysis Continues — NephJC

#384 Updates in Chronic Kidney Disease with Dr. Joel Topf - The Curbsiders

Técnicas, POCUS, Exames & Outros

SGEM#398: ANOTHER AB GETS BUSED – POCUS IN THE ED FOR BILIARY DISEASE | The SGEM

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ARA - Aumento de Risco Absoluto | ECA - Ensaio clínico aleatorizado | ITA - Intention-to-treat Analysis | MA - Meta-análise | MBE - Medicina baseada na evidência | NIT - Non-inferiority trial | NNH - Number needed to harm | NNT - Number needed to treat | PPA - Per protocol analysis | RRA - Redução do Risco Absoluto | RS - Revisão Sistemática